Problems with anti-deps usually occur when one's neurological parameters are in significant ways untypical of the segment that got positive long term results in the initial trials that didn't leave the person with a lifelong dependence or a secondary problem. The brain is complex and the resulting adjustments of one mind / cognitive system will not be exactly like that of another.
Personally, I used a rather heavy anti-depressive (effexor) in my early years which I don't know whether produced side effects or not. I was already neuro-atypical in a visual-thinker high functioning autism manner*.
I developed social anxiety and a neurological disorder later (the latter likely largely unrelated). I think the development of anxiety resulted from a combination of its effects and elsethings, as in hindsight, I used to and would have had another emotional release/pathway available for the situation, though not a very pleasant one at the time. When using the substance, I reacted to it in a more subtle and less conscious way that that resulted in a slow build up towards general social anxiety.
Of course, I would have had another problem rather than anxiety to deal with if I had not utilized it. Something which would have been more apparent and at the moment more vivid to me than the creeping development of social anxiety, but ultimately I think I would have gotten over that problem faster and more easily with the proper interpersonal stimulation to spur me to process that state into something else.
Instead, I fell into what was more like a dead end slowly and stealthily enroaching without me or anyone else noticing or understanding. Effexor ended up as a crutch that made my leg not heal in the proper way for recovering towards my maximal potential, even though it alleviated the most obvious problems at the time.
Of course, in hindsight, I can paint a rosey picture of how things could have gone if the better of the likely courses of reality where to manifest themselves, but that might not have happened and for all I know I could have become worse off due to poor handling or poor stimuli leading to negative fallout from the higher freedom of cognitive potential that not utilizing the substance allowed.
Realistically, for some people, healing at the time is not possible within their current environment, and a crutch and the potential secondary problems can be less bad than the ones one reacts to at the time, and sometimes as mentioned in posts above, a period of using a crutch and having secondary problems can allow oneself to adjust in one's life and mind to a position to better handle the initial problems before or when/if one does decide to end using the cognitive parameter limiting substance. This is assuming the functions it inhibits can/will be restored once one stops utilizing it, which is not certain.
Today, I have problems with not being able to feel sad. I have very high difficulty feeling sad. And the issues I can work out or get temporarily relief from or process in some way through sadness now only adds stress to me, crushing me impersonally and emotionlessly lest I be wary and vigilant.
The rare times I am able to feel sad, i finally feel all the pent up stress dissolving into the vista of what gives me discontent, and am reminded of what relaxation can be like.
* I distinguish between this and aspergers, even though the distinction has been mostly abandoned in the more recent diagnosis lists.
(even though I am not an INTP, and still can't understand the deck of cards thread 
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